File:Serpin mechanism.png

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DescriptionSerpin mechanism.png	English: Serine proteases operate by a two-step catalytic mechanism. First, the substrate (blue) is attacked by the catalytic triad (red) to form an acyl-enzyme intermediate. The intermediate is typically resolved by hydrolysis by water. However, when the reactive centre loop (RCL) of a serpin is attacked, the conformational change (blue arrow) pulls the catalytic triad out of position, preventing it from completing catalysis. (Based on PDB: 1K9O, 1EZX)
Date	19 December 2015
Source	Own work
Author	Thomas Shafee

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	Date/Time	Dimensions	User	Comment
current	09:56, 22 December 2015	1,800 × 1,488 (513 KB)	Evolution and evolvability	Higher resolution
	05:19, 19 December 2015	1,362 × 1,126 (300 KB)	Evolution and evolvability	Minor arrow correction
	05:08, 19 December 2015	1,362 × 1,126 (300 KB)	Evolution and evolvability	added arrow and removed transparency
	05:04, 19 December 2015	1,362 × 1,114 (360 KB)	Evolution and evolvability	Cross-wiki upload from en.wikipedia.org

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